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Men overwhelmingly cite health-related reasons (58%), while women are far more likely to pursue GLP-1s for appearance-based goals (70%)
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Generally, the gastrointestinal side effects are more pronounced with shorter-acting GLP-1RA in comparison to long-acting compounds
In addition, HFD also promotes apoptotic processes at the hypothalamic level 62 , and weight-lowering therapies, as exercise, contribute to mitigate apoptosis in hypothalamic neurons 60
Recent epidemiological data indicate an overall incidence of MASLD ranging from 46.1 to 46.9 new cases per 1,000 person-years, with a prevalence estimated at 30.05% to 32.4%
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